They report instead finding evidence of the mutations reducing function or producing dominant-negative effects, which resulted in reducing tumor suppression effectiveness. In watching the mutations occur, the researchers found no evidence of missense (point) mutations that added functionality to the TP53 suppressor protein. It also means to have authority or influence on another thing. ![]() Other meanings include commanding behavior, powerful and prevailing over all others. The general meaning of dominant is to be in control. To find the answer, the researchers used CRISPR/Cas9 to generate multiple kinds of human leukemia cells (representing the most common kinds of mutations involved with leukemia) that could be used to study the progression of tumors. The word dominant or dominant trait is commonly used in biology. ![]() The work was meant to put to rest a long-running debate in the field regarding how mutations in TP53 that result in cancer alter the function of wild-type TP53. The dominant-negative effect is defined as a circumstance in which a mutation occurs that results in a gene product adversely affecting wild-type gene products-all in the same cell. In this new effort, the researchers have in essence refuted such earlier results-they are suggesting that what really happens is that the mutations that occur exert what they describe as a "dominant-negative" effect-an effect that results in a reduction of activity of wild-type (in its natural, non-mutated form) TP53. For example, a guy who makes improper passes at younger women in the office may be referred. ![]() One of the findings of such studies was that when the gene mutates, it adds new functions to a protein that suppresses tumors. DOM describes an old man who says or does inappropriate things. It was first identified approximately 40 years ago, and since that time, it has been very heavily studied. The tumor protein (TP) 53 is the most often mutated gene in human cancers.
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